Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Democracy, Spirit, and RevitalizationWalter B. Gulick (bio)The assumptions of democracy as an associational ethos of vulnerable life are, first, that we don't already know how best to order our common life and, second, that we don't know what the abstract ideals of empathy, emancipation, and equity entail in the concrete.—Michael Hogue1In American Immanence: Democracy for an Uncertain World, Michael S. Hogue grounds his proposal for a political theology in (...) a critique of American exceptionalism and its supportive "redeemer symbolic."2 In the Anthropocene era, Hogue states, American exceptionalism "legitimates the extraction of diverse forms of value and justifies the externalization of diverse costs" (29) with unconscionable costs to the natural environment and international justice. As indicated in the passage quoted above, Hogue's reaction to the rigid assumptions supportive of American exceptionalism is to offer a humble acknowledgement of political fallibility coupled with what he terms "a theopolitics of resilient democracy" (184; see also 3–6).My concern in this essay is largely practical. I will focus on discerning what intellectual, emotional, and communal resources might be drawn upon to further develop and actually effect the needed changes that Hogue so ably points out. Relatedly, I will inquire into who the most likely candidates are to devote energy to the reconstruction of social structures and practices so that they express values that Americans at their best uphold. Finally, I will reflect upon the role that spiritual ideals and communal practices might play in energizing effective democratic action. [End Page 5]I. Hogue's Critical and Constructive TasksHogue's overriding interest is to outline an epistemic/axiological/environmental/political stance that does not give rise to the various sorts of injustices and dysfunctions that mark the Anthropocene era, especially our allegiance to policies that eventuate in what he calls "climate wickedness." The alternative vision he embraces develops pragmatic naturalism as a method of inquiry and exposition. His reflections are especially indebted to the thought of Dewey, James, and Whitehead (78–82). During a time when e-words are normally associated with forms of electronic communication, Hogue offers instead two trios of e-words with another sort of significance—one that signifies a stance he wishes to overcome and one that communicates what he hopes to achieve. Our current era is unfortunately in thrall, he says, to extraction, externalization, and exception, whereas what we should strive for is a society marked by empathy, emancipation, and equitability. Well put. He presupposes that democratic governance, deeply embedded in American history, ought to serve as the vehicle for achieving what the positive set of e-words promotes. To this end, Hogue quotes appreciatively from Dewey's article, "Democracy is Radical": Democracy "is radical because it requires great change in existing social institutions, economic, legal and cultural" (170). This understanding of democracy slumbers now; what might it take to reawaken it? And if reawakened, what changes might be made to establish the more nearly equitable political influence that is basic to the promise of democracy?Hogue, recognizing in good pragmatic fashion the importance of consequential change, states, "In contrast to foundationalist commitments to antecedents and precedents, pragmatic naturalism commits to a prospective concern with consequents" (80). Foundational commitments to antecedents may certainly impede needed change, but surely attention to the historical events and practices that gave rise to current problems is needed to avoid repeating previous errors. Hogue refers to Whitehead's vision of social symbolism, suggesting that "social change can be catalyzed by the improvised revision of existing symbolic repertoires or the innovative formation or subversive interjection of new symbols" (99). I'm not fully convinced by Whitehead's claim. I suspect that many of our social problems are rooted below the linguistic level in an array of affective issues that elude symbolic adjustment. New strategies are needed to counter the prevalence of fear and resentment in society as promoted for political and commercial reasons and tied to Hogue's strongly voiced recognition that we live in an uncertain world.Here is my understanding of how Hogue both frames our current social and cultural situation and what he says might begin to remediate these circumstances. [End Page... (shrink)

Although there are distinctly American artists-Walt Whitman, Herman Melville, Grandma Moses, Thomas Hart Benton, and Andy Warhol, for example-very little attention has been devoted to formulating any distinctively American characteristics of aesthetic judgment and practice. This volume takes a step in this direction, presenting an introductory essay on the possibility of such a distinctly American tradition, and a collection of essays exploring particular examples from a variety of angles. Some of the essays in this collection extend pragmatist and process insights (...) about the important place aesthetics has in molding and assessing experience. Other essays examine the place of American aesthetics in relation to such particular forms of art as painting, literature, music, and film. Three essays attend to the aesthetic aspects of a flourishing life. In each of the essays, American aesthetics is understood to arise out of deeply felt personal, historical, and cultural backgrounds. Consequently, not only are such relatively abstract notions as harmony, fit, elegance, proportion, and the like involved in aesthetic judgment, but also religious, political, and social factors become embroiled in aesthetic discernment. Thus the ongoing pattern of American aesthetics is shown to be distinguishable from such other varieties of aesthetic thought as analytic aesthetics, New Criticism, and postmodern approaches to aesthetics. (shrink)

Assertion plays a crucial dual role in Frege's conception of logic, a formal and a transcendental one. A recurrent complaint is that Frege's inclusion of the judgement-stroke in the Begriffsschrift is either in tension with his anti-psychologism or wholly superfluous. Assertion, the objection goes, is at best of merely psychological significance. In this paper, I defend Frege against the objection by giving reasons for recognising the central logical significance of assertion in both its formal and its transcendental role.

Are there aspects of human intelligence that artificial intelligence cannot emulate? Harry Collins uses a distinction between tacit aspects of knowing, which cannot be digitized, and explicit aspects, which can be, to formulate an answer to this question. He postulates three purported areas of the tacit and argues that only “collective tacit knowing” cannot be adequately digitized. I argue, first, that Collins’s approach rests upon problematic Cartesian assumptions—particularly his claim that animal knowing is strictly deterministic and, thus, radically different from (...) human knowing. I offer evidence that human linguistic intelligence depends upon embodied forms of animal intelligence. Second, I suggest the development of deep-learning algorithms means that Collins’s mimesis assumption is no longer appropriate; equivalent accomplishment of goals is what counts. However, persons must realize and integrate many goals and also deal with failures; a general-purpose AI capable of integrating all the needs and goals of human existence resists development. Third, I explain how Michael Polanyi’s understanding of tacit knowing, quite different than Collins’s concept of the tacit, exemplifies features that are missing in contemporary AI. I make use of evolutionary theory, studies of animal intelligence, biological insights, individual construction of meaning, and notions of human responsibility to argue for the existence of three categories that distinguish human from artificial intelligence. (shrink)

The Hutchins Commission's notion of media responsibility is being re-invigorated by the Corporate Social Responsibility/sustainability movement among U.S. and European corporations, though media companies tend to lag behind in adopting these programs. One exception is Britain's Guardian News that is, that the concept is too vague and poorly elaborated.

Frege seems committed to the thesis that the senses of the fundamental notions of arithmetic remain stable and are stably grasped by thinkers throughout history. Fully competent practitioners grasp those senses clearly and distinctly, while uncertain practitioners see them, the very same senses, “as if through a mist”. There is thus a common object of the understanding apprehended to a greater or lesser degree by thinkers of diverging conceptual competence. Frege takes the thesis to be a condition for the possibility (...) of the rational intelligibility of mathematical practice. I argue however that the idea that senses could be grasped as a matter of degree is in tension with the constitutive theses that Frege held with regard to sense. Given those theses, there can in fact be no such thing as misty grasp of sense, since any uncertainty as to the logical features of a given sense will entail that one is getting hold of a different sense or of no sense at all. I consider various ways of resolving the tension and conclude that Frege’s thesis cannot be defended if we take it to be a thesis about our competence with concepts. This leaves unresolved what I call the problem of normative guidance, that is, the problem of explaining how the fundamental notions of logic and arithmetic can provide inferential guidance to thinkers. (shrink)

I describe a “logic of creating” inspired by the “existential” argument of the existence of God in St. Thomas Aquinas’s De Ente et Essentia. suggest a modal reading of his reasoning based upon states-of-affairs said to be actual, contingent, necessary and the like. I take “creating” as teasing actuality out of possibility. After explaining the modal logic that I am assuming and relating it to Christian understandings of meaning and being, I present my modal interpretation, contrasting it with the views (...) of three modern philosophers. In an appendix I will analyze the text of St. Thomas’s existential proof. (shrink)

Using the metaphor of a circle with its center, periphery, and radius, this essay explores William Poteat's understanding of the self, or "mindbody," in its dynamic and creative relation to the larger world, or cosmos, identifying the mindbody's prereflective radix with the "center," its boundary or point of interface with the larger world with the "periphery," and its dialectical evolution and articulation of a sense of coherence and meaning in terms of a pretensive and retrotensive "radius.".

This essay examines Michael Polanyi’s notion of tacit knowing and seeks to clarify and elaborate upon its claims. Tacit knowing, which is conscious although inarticulate, must be distinguished from tacit processes, which are largely unconscious. Schematization is explored as a primary tacit process that humans share with all animals. This tacit process organizes and secures, in long-term memory, information of interest provided by receptors and those learned skifls conducive to survival. Human empirical knowing integrates schematized subsidiaries info articulate explicitness through (...) culturally-embedded symbols evoked in terms of felt fittingness. (shrink)

Inappropriately reductive or deterministic appropriations of science haunt Philip Clayton’s otherwise instructive appropriation of Michael Polanyi’s thought for theological and ethical reflection. The work at hand utilizes contemporary complexity theory to augment Polanyi’s notions of emergence and hierarchy and to provide a vision within which moral responsibility and theological inquiry make sense. It sets forth types and orders of emergence that bypass untenable notions of causality, reducibility, and determinism.

In a recent article “From Epistemology to Ontology,” Tihamer Margitay argues that Polanyi fails to establish the necessary correlation he claims between the two levels involved in tacit knowing and corresponding ontological levels. I argue that Margitay correctly shows that such a correspondence does not hold in all cases, but I also point out problems in Margitay’s interpretation of Polanyi and suggest additional bases for ontological claims that go beyond Margitay’s analysis.

Ultimately Michael Polanyi moved from theorizing about reality in terms of three overlapping frameworks of analysis (personal knowing, evolution/ecology, and tacit knowing) to a yet more comprehensive framework of interpretation: meaning construction. An analysis of the dimensions of embodied, symbol drenched meaning construction suggests that the modernist tendency to tether reality to epistemological analysis be replaced by an exploration of three interpenetrating ontological regions: experiences of existential meaning, cultural forms of meaning, and external reality. In support of this view, I (...) make reference to earlier expressions of my work, utilize illustrations from philosophical history, and address comments from my critics. (shrink)

The other articles in this issue plus other recent articles on Polanyi’s ethics have helped clarify Polanyi’s distinctive contribution to ethical theory. This article seeks to integrate these insights with Polanyi’s somewhat diffuse treatment of ethics by suggesting what features would be included in a distinctively Polanyian moral point of view. Grounded in psychological satisfactions, social dynamics, and values and ideals regarded as real, Polanyian ethics incorporates features of deontological, utilitarian, and virtue ethics and would support a practice of moral (...) discovery. (shrink)

Linguistic creativity is the ability to understand indefinitely many previously unencountered sentences. In this paper, I compare Chomsky’s and Ricœur’s contrasting conceptions of this ability, in particular, their divergent views of nonsense. With nonsense, it seems as if syntax is outrunning semantics. Chomsky took this to show that syntax is autonomous of semantics. I propose a reading of Ricœur’s work on metaphor whereby Chomsky’s thesis is modified so that syntax and semantics are declared to be ultimately co-extensive notions.

What does it mean to be a rational language user? What is it to obey linguistic rules? What is the proper account of linguistic competence? A Fregean answer to these questions would make essential appeal to the notion of sense: we are masters of a language to the extent that we are able to recognise the cognitive value of its expressions; we are rational judges regarding truth-value assignments to the extent that we are sensitive to the ways in which the (...) sense of an expression guides us in the semantic evaluation process; and as for obeying rules, it is our ability to respond to how sense directs us, for a particular assertion of a sentence, towards the determination of its truth-value that best exemplifies what it is like to follow a linguistic rule. My thesis explores a cluster of closely interrelated issues arising from these questions. Accordingly, in tracing the routes of sense my dissertation places itself at the intersection of the philosophy of language, linguistics, philosophy of logic, and meta-ethics—and indeed, I end up agreeing with Allan Gibbard that the theory of meaning really belongs to meta-ethical reflection. Chapter 1 introduces some of the main research questions that I try to address in the rest of the thesis. In chapter 2 I state a number of theses which I take to be the defining ones for semanticism. I show that they form a class of jointly incompatible commitments. I choose nonsense as a problem case for compositionality and I argue that it forces the semanticist to abandon either the learnability or the compositionality constraint. The escape route I adopt, going radically minimalist about content, is incompatible with another key semanticist thesis, namely, that grasp of meaning is grasp of truth-conditions. In chapter 3, I consider the account of atomic meanings given by both the semanticist and the pragmaticist and I conclude that on neither account does interpretation come out as a process of rational choice between candidate bearers of content. Again, I suggest the lesson from indeterminacy is that we ought to embrace an ineradicably minimal conception of content. In chapter 4 I turn my attention to the meaning of the logical constants and I argue that indeterminacy worries extend to the very heart of the compositional machinery. Chapter 5 examines the view that logic is the science of reasoning. Unsurprisingly, I conclude that a defence of this claim requires endorsing content-minimalism. In chapter 6 I conclude my dissertation by sketching a radical view of content minimalism and I try to show how it can solve the puzzles I had been considering over the course of the previous chapters. (shrink)

In what manner can philosophy best face world problems? I argue that philosophy's most important contribution to problem solving is not analysis and clarification but synoptic in nature. Relying upon the power of reflection and the scope of imagination as linked to a patient attempt to understand many disciplines, the philosopher ideally seeks to comprehend problems in their many-dimensioned complexity. The disciplines of ecology, evolution, and ethics are especially fruitful in guiding the philosopher seeking to assess the relative worth of (...) things in their emergent inter-relationships. - In the body of the paper I attempt an outline of the outstanding human caused harms, injustices, and instabilities resulting in pain and suffering today. World philosophy today seems sufficiently pluralistic, comprehensive and free of unduly constraining orthodoxies that it can again play a significant role not only in conceptualizing problems but in articulating solutions. Broad visions comparable to Plato's as set forth in the Republic can again be ventured. We need to seek out ways to place into power a council of international philosopher kings and queens offering effective solutions beyond the dictates of partisanship and ideology. I conclude by suggesting five principles that international philosopher kings and queens might be expected to rely upon to bring about a more just global society. (shrink)

In a recent article “From Epistemology to Ontology,” Tihamer Margitay argues that Polanyi fails to establish the necessary correlation he claims between the two levels involved in tacit knowing and corresponding ontological levels. I argue that Margitay correctly shows that such a correspondence does not hold in all cases, but I also point out problems in Margitay’s interpretation of Polanyi and suggest additional bases for ontological claims that go beyond Margitay’s analysis.

Joseph Bracken proposes to modify Whitehead’s tendency to see the comprehensive entities of everyday life as but aggregations of actual occasions. While there are resources in Polanyi’s notion of an emergent cosmos to counter Whitehead’s atomism and reductionism, Bracken’s use of Polanyi’s theory of a morphogenetic field as a corrective is argued to be only partially successful. Bracken must explain how morphogenetic fields evolve and arise. This step would require replacing Whiteheadian reductionism with a principle of ontological parity that honors (...) the reality of interaction between entities and the integration of their operational principles within basic ontological levels and setting forth principles of emergence to explain how these levels and fields arise. (shrink)

This brief essay introduces five articles that (1) explore the relationship between the philosophy of Michael Polanyi and several other philosophers and that (2) suggest ways that Polanyi’s post-critical thought might be enriched by their philosophical insights.

This brief essay introduces five articles that (1) explore the relationship between the philosophy of Michael Polanyi and several other philosophers and that (2) suggest ways that Polanyi’s post-critical thought might be enriched by their philosophical insights.

This brief essay introduces five articles that (1) explore the relationship between the philosophy of Michael Polanyi and several other philosophers and that (2) suggest ways that Polanyi’s post-critical thought might be enriched by their philosophical insights.

This essay critically discusses books not previously reviewed in Tradition and Discovery yet making significant use of Michael Polanyi’s thought. These works suggest Polanyi’s thought continues to play an importanf, if limited, role in contemporary scholarship.

Religious naturalism takes very seriously the meanings inherent in both a scientific understanding of the world and a religious orientation to life well lived. It rejects—as implausible and incompatible with science— the supernaturalism that has dominated Western religious traditions. But can one or more of the varieties of religious naturalism satisfy the fundamental religious needs or yearnings for meaning that have typically been responded to within supernaturalistic worldviews? A challenge facing all types of religious naturalism, if any are to take (...) hold, is to engage these religiously colored needs and yearnings with coherence and integrity.Religious belief and practice typically seem to have more to do with .. (shrink)

Inappropriately reductive or deterministic appropriations of science haunt Philip Clayton’s otherwise instructive appropriation of Michael Polanyi’s thought for theological and ethical reflection. The work at hand utilizes contemporary complexity theory to augment Polanyi’s notions of emergence and hierarchy and to provide a vision within which moral responsibility and theological inquiry make sense. It sets forth types and orders of emergence that bypass untenable notions of causality, reducibility, and determinism.